Eleven years after the events of the Clerks, Dante Hicks (Brian O'Halloran) opens the Quick Stop convenience store to find that it is on fire; Randal Graves (Jeff Anderson) had left the coffee pot on after closing the night before. As a result of the destruction of Quick Stop and the adjacent RST Video, Dante and Randal begin working at a Mooby the Golden Calf fast food restaurant along with Elias (Trevor Fehrman) and their manager List of View Askewniverse characters#Becky Scott (Rosario Dawson). A year later, Dante is planning to leave his minimum wage lifestyle in favor of a family life in Florida with his fiancée Emma Bunting (Jennifer Schwalbach Smith), whose father will provide them with a home and a business to run. This leaves Randal, who fears that with Dante moving to Florida would leave him without his best friend, bitterly disappointed. Jay and Silent Bob (Jason Mewes and Kevin Smith) have since followed Dante and Randal, and now loiter outside of Mooby's. Jay and Silent Bob no longer do drugs after they were arrested for possession and were sent to Drug rehabilitation, and become devout Christians following their release. However, the duo continue selling drugs.

King Leonidas of Sparta leads 300 powerful warriors into an epic and bloody battle at Thermopylae against the massive invading forces of King Xerxes.

In an alternate present-day version of Oakland, telemarketer Cassius Green discovers a magical key to professional success, propelling him into a universe of greed.

In 1980 Dr. Hannibal Lecter attends an orchestral performance of ''A Midsummer Night's Dream (Mendelssohn)'' in Baltimore, Maryland. He is irritated by a flute player who repeatedly misses his part. Later, he hosts a dinner party in his townhouse for the orchestra's board of directors. During conversation, the disappearance of the flute player is brought up. When one of the guests asks about the ''amuse-bouche'' Lecter made, he responds that if he tells her, she might not try it.

Imprisoned on the planet Sakaar, Thor must race against time to return to Asgard and stop Ragnarök, the destruction of his world, at the hands of the powerful and ruthless villain Hela.